Human NR1I2 blocking peptide

Product Overview

Blocking/Immunizing peptide for anti-PXR/NR1I2 antibody

Target

PXR / NR1I2

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Entrez Gene ID

Antigen Description

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]

Function

drug binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; protein binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription coactivator activity; zinc ion binding;

Synonyms

NR1I2; nuclear receptor subfamily 1, group I, member 2; BXR; PAR; PRR; PXR; SAR; SXR; ONR1; PAR1; PAR2; PARq; nuclear receptor subfamily 1 group I member 2; pregnane X receptor; orphan nuclear receptor PXR; orphan nuclear receptor PAR1; steroid and xenobiotic receptor; pregnane X nuclear receptor variant 2;