Anti-NR1I2 (full length) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Rat; Human

Immunogen

Recombinant full length protein, corresponding to amino acids 1-434 of Human PXR (NP_003880.3).

Conjugate

Application Notes

WB: 1μg/ml; ICC/IF: 10μg/ml.

Alternative Names

NR1I2; nuclear receptor subfamily 1, group I, member 2; BXR; PAR; PRR; PXR; SAR; SXR; ONR1; PAR1; PAR2; PARq; nuclear receptor subfamily 1 group I member 2; pregnane X receptor; orphan nuclear receptor PXR; orphan nuclear receptor PAR1; steroid and xenobi

Entrez Gene ID

UniProt ID

Antigen Description

Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.

Pathway

Drug Induction of Bile Acid Pathway; Generic Transcription Pathway; Nuclear Receptors;