Anti-PSMB7 (aa 151-277) polyclonal antibody

Antibody Isotype

IgY

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide, corresponding to C terminal amino acids 151-277 of Human Proteasome 20S beta2.

Conjugate

Application Notes

WB: 1:2000

Alternative Names

PSMB7; proteasome (prosome, macropain) subunit, beta type, 7; proteasome subunit beta type-7; Z; Macropain chain Z; Multicatalytic endopeptidase complex chain Z; Proteasome (prosome macropain) subunit beta type 7; Proteasome beta 7 subunit; Proteasome catalytic subunit 2; Proteasome subunit alpha; Proteasome subunit beta 2; Proteasome subunit beta 7; Proteasome subunit beta type 7; Proteasome subunit beta type-7; Proteasome subunit Z; PSB7_HUMAN; PSMB7; PUP1; macropain chain Z; proteasome subunit Z; proteasome subunit alpha; proteasome subunit beta 7; proteasome catalytic subunit 2; multicatalytic endopeptidase complex chain Z;

Entrez Gene ID

UniProt ID

Antigen Description

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit).

Pathway

APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; Adaptive Immune Syste