Specificity
Widely expressed.
Tag/Conjugate
Unconjugated
SequenceSimilarities
Contains 1 MPN (JAB/Mov34) domain.
Alternative Names
The MPN domain has structural similarity with viral ribonucleases and RNase H, but unlike RNases, it does not bind any metal ions.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Antigen Description
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008]
Function
U5 snRNA binding; U6 snRNA binding; poly(A) RNA binding; protein binding;
Synonyms
PRPF8; pre-mRNA processing factor 8; PRP8; RP13; HPRP8; PRPC8; SNRNP220; pre-mRNA-processing-splicing factor 8; p220; PRP8 homolog; splicing factor Prp8; apoptosis-regulated protein 1; apoptosis-regulated protein 2; 220 kDa U5 snRNP-specific protein; precursor mRNA processing protein; PRP8 pre-mRNA processing factor 8 homolog; U5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8p;
Citations
Publication ()
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COA
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