Human PROX1 peptide

Specificity

Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

Belongs to the Prospero homeobox family.Contains 1 Prospero-type homeobox DNA-binding domain.

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Entrez Gene ID

Antigen Description

The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Function

DBD domain binding; DNA binding; LBD domain binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; ligand-dependent nuclear receptor binding; protein binding; sequence-specific DNA binding; sequence-specifi

Synonyms

PROX1; prospero homeobox 1; prospero homeobox protein 1; prospero-related homeobox 1; homeobox prospero-like protein PROX1;