Anti-PROX1 monoclonal antibody (CABT-24475MC)

Mouse anti-Human PROX1 monoclonal antibody for IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
6H21
Species Reactivity
Chicken, Human, Mouse, Rat
Immunogen
Recombinant protein corresponding to human PROX1.
Conjugate
Unconjugated

Applications


Application Notes
Immunohistochemistry (1:1000) & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
prospero homeobox 1; OTTHUMP00000035023; prospero-related homeobox 1; OTTHUMP00000216821; prospero homeobox protein 1; PROX-1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
PROX1 (Prospero Homeobox 1) is a Protein Coding gene. Diseases associated with PROX1 include kaposiform hemangioendothelioma and angiokeratoma of fordyce. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is PROX2. The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants.
Antigen Description
Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene.
Mouse monoclonal antibody raised against recombinant PROX1. Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. 0The function about PROX1 antigen include DBD domain binding; DNA binding; LBD domain binding; ligand-dependent nuclear receptor binding; protein binding; sequence-specific DNA binding transcription factor activity; sequence-specific enhancer binding RNA polymerase II transcription factor activity; transcription corepressor activity; transcription regulatory region DNA binding.

Citations


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References


Saint-Geniez, M; Kurihara, T; et al. Role of Cell and Matrix-Bound VEGF Isoforms in Lens Development. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 50:311-321(2009).
Wilting, J; Becker, J; et al. Two endothelial cell lines derived from the somite. ANATOMY AND EMBRYOLOGY 211:S57-S63(2006).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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