Anti-PIDD polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide conjugated to KLH derived from within residues 850 to the C-terminus of Human LRDD.

Conjugate

Application Notes

ICC/IF: 1μg/ml
WB: 1μg/ml

Alternative Names

PIDD; p53-induced death domain protein; leucine rich repeats and death domain containing , LRDD; p53-induced protein with a death domain; DKFZp434D229; MGC16925; DKFZp434D229; Leucine rich repeats and death domain containing; Leucine-rich repeats and death domain containing; MGC16925; p53-induced protein with a death domain; PIDD; leucine-rich repeats and death domain containing; leucine-rich repeat and death domain-containing protein; LRDD;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants.

Pathway

Caspase cascade in apoptosis, organism-specific biosystem; DNA damage response, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; p53 signaling pathway, organism-specific biosystem; p53 signaling pathway, conserved biosystem;