Anti-PIDD monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human LRDD is used for rabbit immunization.

Conjugate

Alternative Names

PIDD; p53-induced death domain protein; LRDD; p53-induced protein with a death domain; leucine-rich repeats and death domain containing; leucine-rich repeat and death domain-containing protein;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants.

Pathway

Caspase cascade in apoptosis; DNA damage response; Direct p53 effectors; NF-kappa B signaling pathway; miRNA Regulation of DNA Damage Response; p53 signaling pathway; p53 signaling pathway.