This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Function
SUMO ligase activity; enzyme binding; nucleic acid binding; potassium channel regulator activity; protein C-terminus binding; protein N-terminus binding; protein binding; zinc ion binding
Synonyms
PIAS3; protein inhibitor of activated STAT, 3; ZMIZ5; E3 SUMO-protein ligase PIAS3; zinc finger, MIZ-type containing 5; protein inhibitor of activated STAT protein 3
Citations
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