Anti-PIAS3 (aa 453-550) polyclonal antibody

Species Reactivity

Human

Immunogen

PIAS3 (NP_006090, 453 a.a. ~ 550 a.a) partial recombinant protein with GST tag. The sequence is PPTKKHCSVTSAAIPALPGSKGVLTSGHQPSSVLRSPAMGTLGGDFLSSLPLHEYPPAFP LGADIQGLDLFSFLQTESQHYGPSVITSLDEQDALGHF

Conjugate

Alternative Names

PIAS3; protein inhibitor of activated STAT, 3; ZMIZ5; E3 SUMO-protein ligase PIAS3; zinc finger, MIZ-type containing 5; protein inhibitor of activated STAT protein 3;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined.

Pathway

Androgen receptor signaling pathway; Coregulation of Androgen receptor activity; Interferon type I; Jak-STAT signaling pathway.