This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]
Function
metal ion binding; phosphoprotein phosphatase activity; protein binding
Synonyms
PHLPP1; PH domain and leucine rich repeat protein phosphatase 1; SCOP; PHLPP; PLEKHE1; PH domain leucine-rich repeat-containing protein phosphatase 1; SCN circadian oscillatory protein; PH domain-containing family E member 1; suprachiasmatic nucleus circadian oscillatory protein; pleckstrin homology domain containing, family E (with leucine rich repeats) member 1
Citations
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