Anti-PHLPP1 (aa 1200-1250) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide: DNREALYGVF DGDRNVEVPY LLQCTMSDIL AEELQKTKNE EEYMVNTFIV M, corresponding to amino acids 1200-1250 of Human PHLPP

Conjugate

Application Notes

WB: 1/500 - 1/1000;

Alternative Names

PHLPP1; PH domain and leucine rich repeat protein phosphatase 1; SCOP; PHLPP; PLEKHE1; PH domain leucine-rich repeat-containing protein phosphatase 1; SCN circadian oscillatory protein; PH domain-containing family E member 1; suprachiasmatic nucleus circa

Entrez Gene ID

UniProt ID

Antigen Description

Protein phosphatase that mediates dephosphorylation of Ser-473 of AKT1, Ser-660 of PRKCB isoform beta-II and Ser-657 of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of Ser-473 of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. May act as a negative regulator of K-Ras signaling in membrane rafts.

Pathway

Adaptive Immune System; DAP12 signaling; Downstream signal transduction; Downstream signaling of activated FGFR