Human PSENEN blocking peptide

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

13 amino acids near the carboxy terminus of human PEN2.

Purity

> 95 % by SDS-PAGE.

Format

Lyophilized

Preservative

None

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Reconstitution

PSENEN peptide is supplied as 1mg of dried peptide. When the peptide is reconstituted in 1 mL strile water, the concentration will be 1 mg/mL.

Introduction

Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimers disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Entrez Gene ID

Synonyms

PSENEN; presenilin enhancer gamma secretase subunit; PEN2; PEN-2; MDS033; MSTP064; gamma-secretase subunit PEN-2; presenilin enhancer 2 homolog; hematopoietic stem/progenitor cells protein MDS033;