Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide corresponding to residues in Human PEN2 (UniProt Q9NZ42).
Applications
Application Notes
WB: 1/1000 - 1/10000; IHC-P: 1/100 - 1/250; ICC/IF: 1/100 - 1/250; Flow Cyt: 1/100 - 1/500.
Target
Alternative Names
PSENEN; presenilin enhancer 2 homolog (C. elegans); gamma-secretase subunit PEN-2; PEN2; hematopoietic stem/progenitor cells protein MDS033; PEN-2; MDS033; MSTP064;
Product Background
Antigen Description
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
Pathway
Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; NRIF signals cell death from the nucleus, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem.
Citations
Publication ()
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COA
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