Tag/Conjugate
Unconjugated
Purity
> 95 % by SDS-PAGE.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Reconstitution
PDE4D peptide is supplied as 1mg of dried peptide. When the peptide is reconstituted in 1 mL strile water, the concentration will be 1 mg/mL.
Introduction
This gene encodes one of four mammalian counterparts to the fruit fly dunce gene. The encoded protein has 3,5-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
Synonyms
PDE4D; phosphodiesterase 4D, cAMP-specific; DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2; cAMP-specific 3,5-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D6; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila);
Citations
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Iona, S; Cuomo, M; et al. Characterization of the rolipram-sensitive, cyclic AMP-specific phosphodiesterases: Identification and differential expression of immunologically distinct forms in the rat brain. MOLECULAR PHARMACOLOGY 53:23-32(1998).
Richter, W; Jin, SLC; et al. Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are, differentially expressed and regulated in rat tissue. BIOCHEMICAL JOURNAL 388:803-811(2005).