This gene belongs to the protocadherin family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing seven cadherin repeats, a transmembrane domain, and a cytoplasmic tail that differs from those of the classical cadherins. This gene is located on the Y chromosome in a block of X/Y homology and is very closely related to its paralog on the X chromosome. The protein is thought to play a role in cell-cell recognition during development of the central nervous system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Function
calcium ion binding;
Synonyms
PCDH11Y; protocadherin 11 Y-linked; PCDH22, protocadherin 22; protocadherin-11 Y-linked; PCDHY; PCDH-Y; protocadherin Y; protocadherin 22; protocadherin-22; protocadherin-PC; protocadherin prostate cancer; protocadherin on the Y chromosome; PCDH22; PCDH-PC;
Citations
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Priddle, TH; Crow, TJ; et al. Protocadherin 11X/Y a Human-Specific Gene Pair: an Immunohistochemical Survey of Fetal and Adult Brains. CEREBRAL CORTEX 23:1933-1941(2013).
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