Human NFE2L2 [His]

Name: NFE2L2 [His]
SKU: DAGH019
Rating: 5 (1 reviews)

NFE2L2 [His], recombinant protein from E. coli

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COA

SDS

Datasheet

Nature

Recombinant

Tag/Conjugate

His

Molecular Weight

26 kDa

Purity

>95% by SDS-PAGE

Preservative

None

Storage

-80°C

Antigen Description

NFE2L2 protein is encoded by NFE2L2 gene. It is a basic leucine zipper protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.

Keywords

NFE2L2; nuclear factor, erythroid 2-like 2; NRF2; nuclear factor erythroid 2-related factor 2; HEBP1; NFE2-related factor 2; NF-E2-related factor 2; nuclear factor erythroid-derived 2-like 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor, erythroid derived 2, like 2

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Datasheet

Certificate of Analysis

Safety Data Sheet

Customer Reviews

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Body condition alters glutathione and nuclear factor erythroid 2-like 2 (NFE2L2)?related antioxidant network abundance in subcutaneous adipose tissue of periparturient Holstein cows

JOURNAL OF DAIRY SCIENCE

Authors: Liang, Y.; Alharthi, A. S.; Bucktrout, R.; Elolimy, A. A.; Lopreiato, V.; Martinez-Cortes, I.; Xu, C.; Fernandez, C.; Trevisi, E.; Loor, J. J.

Abstract

Transcriptomic profiling identifies a critical role of Nrf2 in regulating the inflammatory response to fly ash particles in mouse lung

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Authors: Zhang, Jingwen; Cui, Huiling; Namani, Akhileshwar; Yao, Jun; Deng, Hong; Tang, Xiuwen; Wang, Xiu Jun

Abstract

Exposure to combustion-derived nanoparticles is recognized as a major health hazard, but the molecular responses are still insufficiently described. The transcription factor erythroid 2-related factor 2 (Nrf2, also known as NFE2L2) is a master regulator of the pulmonary defense system against insults by particulate matter. However, its downstream molecular processes are not fully characterized. In the current study, BALB/c wild-type (WT) and Nrf2(-/-) mice were exposed by intranasal administration to fly ash particles (F3-S; 20 mg/kg BW), which were collected from a municipal waste incinerator in China, for three consecutive days. Using a comparative transcriptomics approach, the pulmonary global gene expression profiles to F3-S exposure were characterized for both genotypes. The preponderance of the differentially-expressed genes (DEGs) in WT mice induced by the fly ash particles, was related to inflammation. Functional enrichment and molecular pathway mapping of the DEGs specific to Nrf2(-/-) mice exposed to the particles revealed that all of the top 10 perturbed molecular pathways were associated with the inflammatory response. Our study identified a transcriptional signature related to the initial pulmonary injury in mouse upon fly ash exposure, and suggests an anti-inflammatory role of Nrf2 in protecting the lung against such exposure.