The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]
Function
ATP binding
Synonyms
NLRP14; NLR family, pyrin domain containing 14; NOD5; PAN8; GC-LRR; NALP14; CLR11.2; NACHT, LRR and PYD domains-containing protein 14; NACHT, LRR and PYD containing protein 14; NACHT, leucine rich repeat and PYD containing 14; nucleotide-binding oligomerization domain protein 5; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 14
Citations
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