Specifications
Immunogen
Recombinant GST fusion protein corresponding to C-terminus 242 amino acids of human SMARCA4.
Applications
Application Notes
WB (10 mg/mL) & The optimal working dilution should be determined by the end user.
Target
Alternative Names
SWI/SNF related, matrix associated, actin dependent regulator of chromatin,subfamily a, member 4; BRG1-associated factor 190A; BRG1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatinsubfamily A member 4; BAF190; RTPS2; FLJ39786; bra
Product Background
Antigen Description
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Multiple transcript variants encoding different isoforms have been found for this gene.
Mouse monoclonal antibody raised against partial recombinant SMARCA4.
Pathway
Direct p53 effectors, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem; Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem; Regulation of retinoblastoma protein, organism-specific biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem
Citations
Publication ()
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COA
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