Anti-SMARCA4 (aa 1451-1550) polyclonal antibody

Species Reactivity

Human

Immunogen

SMARCA4 (NP_003063, 1451 a.a. ~ 1550 a.a) partial recombinant protein with GST tag. The sequence is LSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKI KERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDS

Conjugate

Alternative Names

SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; BRG1; SNF2; SWI2; MRD16; RTPS2; BAF190; SNF2L4; SNF2LB; hSNF2b; BAF190A; transcription activator BRG1; SNF2-beta; SNF2-like 4; protein BRG-1; nucle

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Pathway

Direct p53 effectors; Integrated Breast Cancer Pathway; Regulation of Wnt-mediated beta catenin signaling and target gene transcription; Signal Transduction