Anti-SGCA monoclonal antibody, clone 4D5

Antibody Isotype

IgG2b

Clone

4D5

Species Reactivity

Human

Immunogen

SGCA (NP_000014, 26 a.a. ~ 134 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein); 50-DAG; DMDA2; 50kD DAG; LGMD2D; OTTHUMP00000221053; ADL; OTTHUMP00000221059; DAG2; alpha-SG; A2; alpha-sarcoglycan; SCARMD1; dystroglycan-2; adhalin; 50 kDa dystrophin-associated glycoprotein

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
Mouse monoclonal antibody raised against a partial recombinant SGCA.

Pathway

Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem; Hypertrophic cardiomyopathy (HCM), organism-specific biosystem; Hypertrophic cardiomyopathy (HCM), conserved biosystem.