Anti-PEX11A monoclonal antibody (CABT-20114MH)

Mouse anti-Human PEX11A monoclonal antibody for WB, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
4C2
Species Reactivity
Human
Immunogen
PEX11A (NP_003838, 1 a.a. ~ 94 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
peroxisomal biogenesis factor 11 alpha; hsPEX11p; Peroxisomal biogenesis factor 11A; peroxin-11A; MGC119947; peroxisomal membrane protein 11A
Entrez Gene ID
UniProt ID

Product Background


Gene summary
PEX11A (Peroxisomal Biogenesis Factor 11 Alpha) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is PEX11B. This gene is a member of the PEX11 family, which is composed of membrane elongation factors involved in regulation of peroxisome maintenance and proliferation. This gene product interacts with peroxisomal membrane protein 19 and may respond to outside stimuli to increase peroxisome abundance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Antigen Description
Peroxisomal membrane protein 11A is a protein that in humans is encoded by the PEX11A gene.
Mouse monoclonal antibody raised against a partial recombinant PEX11A. May be involved in peroxisomal proliferation and may regulate peroxisomes division (PubMed:9792670). May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity). Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455).
Pathway
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Peroxisome, organism-specific biosystem; Peroxisome, conserved biosystem; Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem.

Citations


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References


Cherkaoui-Malki, M; Meyer, CM; et al. Identification of novel peroxisome proliferator-activated receptor alpha (PRAR alpha) target genes in mouse liver using cDNA microarray analysis. GENE EXPRESSION 9:291-304(2001).

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