Mouse anti-Human INPP5A monoclonal antibody for WB, IP, sELISA, ELISA
INPP5A (Inositol Polyphosphate-5-Phosphatase A) is a Protein Coding gene. Diseases associated with INPP5A include x-linked disease and joubert syndrome 1. Among its related pathways are Metabolism and Inositol phosphate metabolism (KEGG). GO annotations related to this gene include inositol-polyphosphate 5-phosphatase activity and inositol-1,4,5-trisphosphate 5-phosphatase activity. The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.
The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.
Mouse monoclonal antibody raised against a partial recombinant INPP5A. Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction. Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene. 0The function about INPP5A antigen include PH domain binding; hydrolase activity; inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity; inositol or phosphatidylinositol phosphatase activity; inositol-1,4,5-trisphosphate 5-phosphatase activity; inositol-polyphosphate 5-phosphatase activity.
1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), conserved biosystem; D-myo-inositol (1,3,4)-trisphosphate biosynthesis, conserved biosystem; D-myo-inositol (1,4,5)-trisphosphate degradation, conserved biosystem; Inositol phosphate metabolism, organism-specific biosystem; Inositol phosphate metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem.
Bassi, CL; Mello, SS; et al. Transcriptional changes in U343 MG-a glioblastoma cell line exposed to ionizing radiation. HUMAN & EXPERIMENTAL TOXICOLOGY 27:919-929(2008).
Sekulic, A; Pittelkow, M; et al. Inositol polyphosphate-5-phosphatase (INPP5A) expression is associated with increased differentiation and decreased proliferative capacity of normal human keratinocytes. JOURNAL OF INVESTIGATIVE DERMATOLOGY 130:S84-S84(2010).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.