Anti-INPP5A monoclonal antibody (CABT-14330MH)

Mouse anti-Human INPP5A monoclonal antibody for WB, IP, sELISA, ELISA Datasheet

Online Inquiry Add to basket   

Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
4E9
Species Reactivity
Human
Immunogen
INPP5A (NP_005530, 288 a.a. ~ 388 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
inositol polyphosphate-5-phosphatase, 40kDa; CTCL tumor antigen HD-CL-02; 5PTASE; inositol trisphosphate-5-phosphatase, 40kD; inositol polyphosphate-5-phosphatase, 40kD; InsP3 5-phosphatase
Entrez Gene ID
UniProt ID

Product Background


Gene summary
INPP5A (Inositol Polyphosphate-5-Phosphatase A) is a Protein Coding gene. Diseases associated with INPP5A include x-linked disease and joubert syndrome 1. Among its related pathways are Metabolism and Inositol phosphate metabolism (KEGG). GO annotations related to this gene include inositol-polyphosphate 5-phosphatase activity and inositol-1,4,5-trisphosphate 5-phosphatase activity. The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.
Antigen Description
The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.
Mouse monoclonal antibody raised against a partial recombinant INPP5A. Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction. Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene. 0The function about INPP5A antigen include PH domain binding; hydrolase activity; inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity; inositol or phosphatidylinositol phosphatase activity; inositol-1,4,5-trisphosphate 5-phosphatase activity; inositol-polyphosphate 5-phosphatase activity.
Pathway
1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), conserved biosystem; D-myo-inositol (1,3,4)-trisphosphate biosynthesis, conserved biosystem; D-myo-inositol (1,4,5)-trisphosphate degradation, conserved biosystem; Inositol phosphate metabolism, organism-specific biosystem; Inositol phosphate metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem.

Citations


Have you cited CABT-14330MH in a publication? Let us know and earn a reward for your research.

References


Hostetter, G; Kim, SY; et al. Random DNA fragmentation allows detection of single-copy, single-exon alterations of copy number by oligonucleotide array CGH in clinical FFPE samples. NUCLEIC ACIDS RESEARCH 38:-(2010).
Windhorst, S; Minge, D; et al. Inositol-1,4,5-trisphosphate 3-kinase A regulates dendritic morphology and shapes synaptic Ca2+ transients. CELLULAR SIGNALLING 24:750-757(2012).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

Customer Reviews


Write a review, share your experiences with others and get rewarded !

Online Inquiry

Name
Phone *
E-mail Address *
Service & Products Interested *
Project Description
Verification Code * Please input "diagnostics" as verification code.

Online Inquiry

Order Info: Anti-INPP5A monoclonal antibody

Online Inquiry
  Interested in larger quantities ? request a quote!
  Protocol may be improved. Please feel free to contact us to obtain the latest version.!
  15% off your first purchase

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

OUR PROMISE TO YOU Guaranteed product quality expert customer support

Inquiry Basket