This is an intronless gene that is involved in cholesterol and lipid metabolism. The encoded protein is a membrane protein and contains clusters of histidine residues essential for catalytic activity. Unlike most other sterol hydroxylases, this enzyme is a member of a small family of enzymes that utilize diiron cofactors to catalyze the hydroxylation of hydrophobic substrates. Mouse monoclonal antibody raised against a partial recombinant CH25H.
Pathway
Bile acid and bile salt metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Primary bile acid biosynthesis, organism-specific biosystem; Primary bile acid biosynthesis, conserved biosystem; Synthesis of bile acids and bile salts, organism-specific biosystem.
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