Anti-CD81 monoclonal antibody, clone 3C8

Antibody Isotype

IgG1

Clone

3C8

Species Reactivity

Human

Immunogen

CD81 (AAH02978, 25 a.a. ~ 127 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

TAPA-1; TSPAN28; S5.7; TAPA1; tetraspanin-28; tspan-28; 26 kDa cell surface protein TAPA-1; CVID6; Target of the antiproliferative antibody 1; CD81 antigen; OTTHUMP00000011528; OTTHUMP00000011529; OTTHUMP00000229004; OTTHUMP00000229005; OTTHUMP00000229006

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies.
Mouse monoclonal antibody raised against a partial recombinant CD81.

Pathway

Adaptive Immunity Signaling, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem