Anti-ADAMTS4 monoclonal antibody, clone 3B7

Antibody Isotype

IgG1

Clone

3B7

Species Reactivity

Human

Immunogen

ADAMTS4 (AAH63293, 693 a.a. ~ 803 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADAM-TS 4; ADMP-1; EC 3.4.24.82; KIAA0688; A disintegrin and metalloproteinase with thrombospondin motifs 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospo

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
Mouse monoclonal antibody raised against a partial recombinant ADAMTS4.

Pathway

Endochondral Ossification, organism-specific biosystem