Synthetic peptide, corresponding to a region within N terminal amino acids 56-105 (ASLLPLAWSA SPLPREEEIV FPEKLNGSSI IPGSGVPARL LYRLPAFGEI) of Rat ADAMTS4 (NP_076449).
Conjugate
Unconjugated
Applications
Application Notes
WB: 1 μg/ml.
Target
Alternative Names
ADAMTS4; ADAM metallopeptidase with thrombospondin type 1 motif, 4; A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAMTS-4; ADAM-TS 4; Aggrecanase; aggrecanase-1; a disintegrin and metallopeptidase with thrombospondin motifs
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the 392-Glu--Ala-393 site.
Pathway
Endochondral Ossification;
Citations
Publication ()
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