Anti-CD46 monoclonal antibody, clone NFN-369

Antibody Isotype

IgG1

Clone

NFN-369

Species Reactivity

Bovine; Human

Immunogen

Native purified CD46 from human T cell line HPB-ALL.

Conjugate

Alternative Names

CD46 molecule, complement regulatory protein; AHUS2; TLX; OTTHUMP00000034707; MCP; OTTHUMP00000216787; MGC26544; complement membrane cofactor protein; TRA2.10; measles virus receptor; antigen identified by monoclonal antibody TRA-2-10; membrane cofactor p

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
Mouse monoclonal antibody raised against native CD46.

Pathway

Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Measles, organism-specific biosystem; Measles, conserved biosystem