Anti-CD46 monoclonal antibody, clone NN21

Antibody Isotype

IgG2a

Clone

NN21

Species Reactivity

Mouse; Rat

Immunogen

Recombinant fragment corresponding to Mouse CD46. Fused to Human Fc.Database link: O88174

Conjugate

Application Notes

Flow Cyt: 1/50; WB: 1/50; IHC-Fr: 1/50.

Alternative Names

CD46; CD46 antigen, complement regulatory protein; membrane cofactor protein; Mcp;

Entrez Gene ID

UniProt ID

Antigen Description

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Pathway

Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Measles, organism-specific biosystem; Measles, conserved biosystem;