Product Overview
Blocking/Immunizing peptide for anti-MS2 /ADAM8/CD156 antibody
Target
MS2 / ADAM8 / CD156
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.
Function
calcium ion binding; cell adhesion molecule binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; protein self-association; zinc ion binding;
Synonyms
ADAM8; ADAM metallopeptidase domain 8; a disintegrin and metalloproteinase domain 8; disintegrin and metalloproteinase domain-containing protein 8; CD156; MS2; cell surface antigen MS2; human leukocyte differentiation antigen; MGC134985;
Citations
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Bakshi, S; Zhang, X; et al. Transcriptome analyses in normal prostate epithelial cells exposed to low-dose cadmium: Oncogenic and immunomodulations involving the action of tumor necrosis factor. ENVIRONMENTAL HEALTH PERSPECTIVES 116:769-776(2008).
Mahoney, ET; Benton, RL; et al. ADAM8 Is Selectively Up-Regulated in Endothelial Cells and Is Associated With Angiogenesis After Spinal Cord Injury in Adult Mice. JOURNAL OF COMPARATIVE NEUROLOGY 512:243-255(2009).