This paper proposes a special petrogenetic model for mafic microgranular enclaves (MMEs) based on a systematic study on the Sangxinri pluton in the middle part of the northern Lhasa Block, Tibet, China. The MMEs found in the Sangxinri host monzogranite are composed of monzonite porphyry to granodiorite porphyry, which usually present axiolite with an compactly cement with host rocks probably caused by weathering. The MMEs are more basic than the host rocks with higher Na2O, CaO, Mg0 and Fe2O3 T contents. The MMEs have distinct REE characteristics from the host rocks and more variable REE contents than the host rocks. The most basic MME samples have the highest REE contents, while the most acid MME samples have lowest REE contents, indicative of reducing REE contents with increase of SiO2. With evolution of the magma from the MMEs to the host monzogranite, the REE contents rise to a high level. Both the MMEs and host rocks show characteristics of arc rocks with enrichments in large ion lithophile elements (LILEs) Rb, Cs, K, etc., but depletions in high field strength elements (HFSEs) Nb, Ta and Ti etc. and Sr and Ba elements. Zircon LA-ICP-MS U-Pb dating obtains a 75.6 +/- 1. 2Ma age and a 71. 8 +/- 0. 6Ma age for the MMEs and host rocks, respectively. Although the MMEs are 4Myr earlier than the host rocks, they have consistent zircon Lu-Hf isotopes. Synthesizing above petrography, geochemistry and isotopic evidences, we suggest the MMEs are derived from the same source rocks with host rocks. The initial magma experienced various degree of K -bearing hornblende fractional crystallization in the parent magma chamber, and then emplaced along with the early tectonic fault and formed the MMEs. With aggravation of the tectonic motion, massive magma experienced further differentiation upwelled, wrapped and carried the earlier formed MMEs (in semiplastic) to subsurface. The most probable petrogenetic model for the Sangxinri MMEs is magma mingling between the magmas from different periods of the same sourced rock.