Anti-MME monoclonal antibody, clone 4H0E20

Name: Anti-MME monoclonal antibody, clone 4H0E20
SKU: DCABH-12378
Rating: 5 (1 reviews)

Mouse anti-Human MME monoclonal antibody for WB, IHC-P, ELISA

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COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG1

Clone

4H0E20

Species Reactivity

Human

Immunogen

Recombinant protein corresponding to human MME.

Conjugate

Unconjugated

Applications

Application Notes

ELISA (1:10000); WB (1:500-1:2000); Immunohistochemistry (1:200-1:1000) & The optimal working dilution should be determined by the end user.

Target

Alternative Names

MME; membrane metallo-endopeptidase; neprilysin; CALLA; CD10; enkephalinase; NEP; neutral endopeptidase; atriopeptidase; skin fibroblast elastase; neutral endopeptidase 24.11; membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase varian

Entrez Gene ID

4311

UniProt ID

P08473

Product Background

Antigen Description

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5 untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.

Pathway

Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Protein digestion and absorption, organism-specific biosystem; Protein digestion and absorption, conserved biosystem; Renin-angiotensin system, organism-specific biosystem;

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

ON A GENERALIZATION OF THE POSITIVE EXPONENTIAL FAMILY OF DISTRIBUTIONS AND THE ESTIMATION OF RELIABILITY CHARACTERISTICS

STATISTICA

Authors: Kumar, Surinder; Chaturvedi, Aditi

Abstract

A generalization of positive exponential family of distributions developed by Liang (2008) is taken into consideration. Its properties are studied. Two measures of reliability are discussed. Uniformly minimum variance unbiased estimators (UMVUES), maximum likelihood estimators (MLES) and method of moment estimators (MMES) are developed for the reliability functions. The performances of three types of estimators are compared through Monte Carlo simulation. Real life data sets are also analyzed.

Quasi-stationary extratropical wave trains associated with distinct tropical Pacific seasonal mean convection patterns: observational and AMIP model results

CLIMATE DYNAMICS

Authors: Ding, Shuoyi; Chen, Wen; Graf, Hans-F.; Chen, Zhang; Ma, Tianjiao

Abstract

In this paper, mechanisms for the formation of quasi-stationary extratropical wave trains associated with four distinct winter patterns of seasonal mean tropical Pacific convection anomalies, including the western CP (W-CP) pattern, La Nina (LN) pattern, CP El Nino (CPEN) pattern and EP El Nino (EPEN) pattern, are investigated by utilizing observational and six Atmospheric Model Intercomparison Project Phase 5 (AMIP5) high-skilled models (ACCESS1.0, CanAM4, CCSM4, CMCC-CM, HadGEM2-A, MPI-ESM-LR) datasets. The observational results show that tropical Pacific forcing induces upper-level anomalous Rossby wave source that force vorticity over the central North Pacific through modulating the local Hadley circulation, then excite eastward propagation of quasi-stationary planetary waves penetrating into the North Atlantic, and finally establish the associated teleconnections in mid- and high-latitudes by local synoptic eddy-mean flow interaction. Different structures of wave trains may be explained by evident differences in intensity and scale of the extratropical vorticity forcing originating from distinct convection anomalies over the tropical Pacific. The MME results further confirm the possible physical processes obtained from observations, but there still exist some significant differences. These cover the North Pacific and North America and can possibly be attributed to the models' simulation ability of extratropical vorticity forcing and local storm track intensity. In addition, the stratosphere-troposphere interaction plays an important role for extratropical atmospheric circulation anomalies. The stratospheric polar vortex not only modulates the underlying wave train, especially for the North Atlantic/Europe sector, but is also affected by the upper-tropospheric disturbance in high-latitudes through the upward wave activity flux.