Anti-MED23 monoclonal antibody, clone 5I7

Antibody Isotype

IgG2a

Clone

5I7

Species Reactivity

Human

Immunogen

CRSP3 (NP_004821, 531 aa ~ 631 aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

mediator complex subunit 23; CRSP133; DRIP130; DKFZp434H0117; CRSP130; OTTHUMP00000017207; Activator-recruited cofactor 130 kDa component; SUR-2; Cofactor required for Sp1 transcriptional activation subunit 3; mediator of RNA polymerase II transcription subunit 23; ARC130; vitamin D3 receptor interacting protein; CRSP3; KIAA1216; SUR2; CRSP complex subunit 3; hSur-2; cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa; Protein sur-2 homolog; 130 kDa transcriptional co-activator; Transcriptional coactivator CRSP130; 133 kDa transcriptional co-activator; Vitamin D3 receptor-interacting protein complex 130 kDa component; OTTHUMP00000017204; OTTHUMP00000017205; OTTHUMP00000017206; OTTHUMP00000017208

Entrez Gene ID

UniProt ID

Antigen Description

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.Mouse monoclonal antibody raised against a partial recombinant CRSP3.

Pathway

Diabetes pathways, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystem