Synthetic Human MBD2 blocking peptide for Apuri, BL, ELISA
Blocking/Immunizing peptide for anti-MBD2 (isoform 1) antibody
Human, Mouse, Dog, Rat
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Shipped at ambient temperature, store at -20°C.
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
C2H2 zinc finger domain binding; DNA binding; chromatin binding; mRNA binding; methyl-CpG binding; methyl-CpG binding; protein binding; protein domain specific binding; satellite DNA binding; siRNA binding;
MBD2; methyl-CpG binding domain protein 2; methyl-CpG-binding domain protein 2; demethylase; DMTase; NY-CO-41; DKFZp586O0821;