Product Overview
Blocking/Immunizing peptide for anti-MARCH-IV antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
Function
ubiquitin-protein ligase activity; zinc ion binding;
Synonyms
MARCH4; membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase; RNF174; MARCH-IV; E3 ubiquitin-protein ligase MARCH4; RING finger protein 174; membrane-associated RING-CH protein IV; membrane-associated RING finger protein 4;
Citations
Publication ()
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COA
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