Anti-MARCH4 (aa 321-410) polyclonal antibody

Species Reactivity

Human

Immunogen

40972 (NP_065865, 321 a.a. ~ 410 a.a) partial recombinant protein with GST tag. The sequence is KDLEDQKAGGRTNPRTSSSTQANIPSSEEETAGTPAPEQGPAQAAGHPSGPLSHHHCAYT ILHILSHLRPHEQRSPPGSSRELVMRVTTV

Conjugate

Alternative Names

MARCH4; membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase; RNF174; MARCH-IV; E3 ubiquitin-protein ligase MARCH4; RING finger protein 174; membrane-associated RING-CH protein IV; membrane-associated RING finger protein 4;

Entrez Gene ID

UniProt ID

Antigen Description

MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]