Human MARCH1 blocking peptide

Product Overview

Blocking/Immunizing peptide for anti-MARCH-I antibody

Target

MARCH-I

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Entrez Gene ID

Antigen Description

MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010]

Function

MHC protein binding; ubiquitin-protein ligase activity; zinc ion binding;

Synonyms

MARCH1; membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase; RNF171; MARCH-I; E3 ubiquitin-protein ligase MARCH1; RING finger protein 171; membrane-associated RING-CH protein I; membrane-associated RING finger protein 1;