Anti-MARCH1 (aa 1-99) polyclonal antibody

Species Reactivity

Human

Immunogen

40969 (NP_060393, 1 a.a. ~ 99 a.a) partial recombinant protein with GST tag. The sequence is MTSSHVCCNFLNMWKKSKISTMYYLNQDAKLSNLFLQASSPTTGTAPRSQSRLSVCPSTQ DICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIK

Conjugate

Alternative Names

MARCH1; membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase; RNF171; MARCH-I; E3 ubiquitin-protein ligase MARCH1; RING finger protein 171; membrane-associated RING-CH protein I; membrane-associated RING finger protein 1;

Entrez Gene ID

UniProt ID

Antigen Description

MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010]