Product Overview
Blocking/Immunizing peptide for anti-MAN2A1 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013]
Function
alpha-mannosidase activity; carbohydrate binding; hydrolase activity, hydrolyzing N-glycosyl compounds; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity; metal ion binding; zinc ion binding;
Synonyms
MAN2A1; mannosidase, alpha, class 2A, member 1; MANA2; alpha-mannosidase 2; golgi integral membrane protein 7; GOLIM7; man II; AMan II; Golgi alpha-mannosidase II; mannosidase, alpha type II; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase; MANII;
Citations
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Crispin, M; Chang, VT; et al. A Human Embryonic Kidney 293T Cell Line Mutated at the Golgi alpha-Mannosidase II Locus. JOURNAL OF BIOLOGICAL CHEMISTRY 284:21684-21695(2009).
Lu, H; Wang, SS; et al. Effect of Swainsonine in Oxytropis kansuensis on Golgi alpha-Mannosidase II Expression in the Brain Tissues of Sprague-Dawley Rats. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 62:7407-7412(2014).