Human KMT2A peptide

Specificity

Heart, lung, brain and T- and B-lymphocytes.

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily.Contains 3 A.T hook DNA-binding domains.Contains 1 bromo domain.Contains 1 CXXC-type zinc finger.Contains 1 FY-rich C-terminal domain.Contains 1 FY-rich N-terminal domain.Contains 3

Alternative Names

the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.The SET domain structure is atypical and is not in an optimal position to have methyltransferase activity. It requires other components of the

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Entrez Gene ID

Antigen Description

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]

Function

AT DNA binding; chromatin binding; histone acetyl-lysine binding; histone methyltransferase activity (H3-K4 specific); histone methyltransferase activity (H3-K4 specific); identical protein binding; protein binding; protein homodimerization activity; sequ

Synonyms

KMT2A; lysine (K)-specific methyltransferase 2A; HRX; MLL; MLL1; TRX1; ALL-1; CXXC7; HTRX1; MLL1A; WDSTS; MLL/GAS7; TET1-MLL; histone-lysine N-methyltransferase 2A; trithorax-like protein; CDK6/MLL fusion protein; MLL/GAS7 fusion protein; MLL/GMPS fusion protein; zinc finger protein HRX; mixed lineage leukemia 1; lysine N-methyltransferase 2A; MLL-AF4 der(11) fusion protein; CXXC-type zinc finger protein 7; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila);