Anti-KMT2A (aa 3561-3670) polyclonal antibody

Species Reactivity

Human

Immunogen

MLL (NP_005924, 3561 a.a. ~ 3670 a.a) partial recombinant protein with GST tag. The sequence is RTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVT QNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLV

Conjugate

Alternative Names

KMT2A; lysine (K)-specific methyltransferase 2A; HRX; MLL; MLL1; TRX1; ALL-1; CXXC7; HTRX1; MLL1A; WDSTS; MLL/GAS7; TET1-MLL; histone-lysine N-methyltransferase 2A; trithorax-like protein; CDK6/MLL fusion protein; MLL/GAS7 fusion protein; MLL/GMPS fusion

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]

Pathway

Lysine degradation; Transcriptional misregulation in cancer.