Specificity
Ubiquitously expressed, with highest levels in testis.
Tag/Conjugate
Unconjugated
SequenceSimilarities
Belongs to the MYST (SAS/MOZ) family.Contains 1 C2HC-type zinc finger.
Alternative Names
The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L.The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Antigen Description
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.
Function
histone acetyltransferase activity; protein binding; sequence-specific DNA binding transcription factor activity; zinc ion binding;
Synonyms
KAT7; K(lysine) acetyltransferase 7; HBO1; HBOA; MYST2; ZC2HC7; histone acetyltransferase KAT7; MYST-2; lysine acetyltransferase 7; histone acetyltransferase MYST2; MYST histone acetyltransferase 2; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; histone acetyltransferase binding to ORC1;
Citations
Publication ()
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COA
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