This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Function
DNA binding; identical protein binding; protein binding; protein homodimerization activity; sequence-specific DNA binding transcription factor activity; transcription cofactor activity; transcription regulatory region DNA binding
Synonyms
IRF3; interferon regulatory factor 3
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