IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]
Function
ATP binding; IkappaB kinase activity; NF-kappaB-inducing kinase activity; protein binding
Synonyms
IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; IKKE; IKKI; IKK-E; IKK-i; inhibitor of nuclear factor kappa-B kinase subunit epsilon; IKK-epsilon; I-kappa-B kinase epsilon; inducible IkappaB kinase; IKK-related kinase epsilon; inducible I kappa-B kinase
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