Alternative Names
Small Nuclear Ribonucleoprotein Polypeptides B; small nuclear ribonucleoprotein polypeptides b and b1
Purity
>80% as determined by SDS-PAGE
Concentration
Batch dependent - please inquire should you have specific requirements
Buffer
Neutral to slightlyalkaline pH; due to purification workup under denaturing conditions presenceof up to 0.02 % SDS (or similar detergents) may be required for maintainingsolubility.
Storage
2-8°C short term, -20°C long term
Introduction
Small nuclearribonucleoprotein-associated proteins B and B" is a protein that in humans isencoded by the SNRPB gene. The protein encoded by this gene is one of severalnuclear proteins that are found in common among U1, U2, U4/U6, and U5 smallribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNAsplicing, and the encoded protein may also play a role in pre-mRNA splicingor snRNP structure. Autoantibodies from patients with systemic lupuserythematosus frequently recognize epitopes on the encoded protein. Twotranscript variants encoding different isoforms (B and B") have been foundfor this gene.
Keywords
SNRPB; SmB/B′ protein; SmB/B′; U1 snRNP-B/B′; Systemic lupus erythematosus; SLE
Citations
Publication ()
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