Anti-SNRPB monoclonal antibody, clone 2C5

Antibody Isotype

IgG1

Clone

2C5

Species Reactivity

Human

Immunogen

SNRPB (NP_003082, 1 a.a. ~ 80 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

SNRPB; small nuclear ribonucleoprotein polypeptides B and B1; SNRPB1; small nuclear ribonucleoprotein-associated proteins B and B; COD; Sm B/B; SmB/SmB; snRNP B; sm-B/Sm-B; Sm protein B/B; B polypeptide of Sm protein; small nuclear ribonucleoprotein polyp

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B) have been found for this gene.

Pathway

Cleavage of Growing Transcript in the Termination Region, organism-specific biosystem; Gene Expression, organism-specific biosystem; Metabolism of non-coding RNA, organism-specific biosystem; Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem; Processing of Capped Intronless Pre-mRNA, organism-specific biosystem; RNA Polymerase II Transcription, organism-specific biosystem; RNA Polymerase II Transcription Termination, organism-specific biosystem;