Alternative Names
SP100; SP100 nuclear antigen
Purity
>80% as determined by SDS-PAGE
Concentration
Batch dependent - please inquire should you have specific requirements
Buffer
16 mM HEPES, 160 mM NaCl, pH 8.0, 20% Glycerol
Introduction
Primary biliary cirrhosis (PBC) is an autoimmune chronic cholestatic liver disease characterized by destruction of intrahepatic bile ducts and development of cirrhosis and liver failure. Serologically, PBC is characterized by the presence of antimitochondrial (AMA, M2) antibodies. The immunological profil of PBC also includes antinuclear antibodies (ANA), presenting two distinct patterns, multiple nuclear dots (MND) and rim-like/membranous patterns in IIF. Sp100 and promyelocytic leukemia antigen account for the MND pattern, and gp210, nucleoporin p62 and lamin B receptor are associated with nuclear membrane staining
Keywords
Sp100; SP100; PML; Promyelocytic leukemia; Primary biliary cholangitis; PBC
Citations
Publication ()
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