Anti-SP100 (aa 250-350) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide conjugated to KLH derived from within residues 250 - 350 of Human SP100. ( Immunogen available as DAG-P1198 )

Conjugate

Application Notes

IHC-P: 1/2000. WB: 1 μg/ml.

Alternative Names

SP100; SP100 nuclear antigen; nuclear antigen Sp100; nuclear autoantigen Sp-100; Lysp100b; Speckled 100 kDa; DKFZp686E07254; FLJ00340; FLJ34579; K297; MYL; Nuclear antigen Sp100; Nuclear autoantigen Sp 100; Nuclear autoantigen Sp-100; Nuclear autoantigen

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein.

Pathway

Cytokine Signaling in Immune system, organism-specific biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; Immune System, organism-specific biosystem; Interferon Signaling, organism-specific biosystem; Interferon gamma signaling, organism-specific biosystem;