Human GLA(Alpha-galactosidase A) ELISA Kit

Context: Statins have been linked to the development of diabetes and atherosclerotic plaque calcification in patients with cardiac disease. Objective: To determine the association between statin use and statin characteristics and insulin resistance and abdominal aortic calcification (AAC) in participants of the Canadian Multicentre Osteoporosis Study (CaMos). Design: Observational study. Setting: General community. Participants: Nondiabetic participants of the Kingston CaMos site Intervention: Insulin resistance and AAC in statin users and nonstatin users were compared with and without the inclusion of a propensity score (PS) to be on a statin. The covariates of hypertension, sex, body mass index, smoking, kidney stones, and age that were included in the PS were selected based on clinical judgment confirmed by the statistical analysis of a difference between statin users and nonstatin users. Main Outcome Measures: Insulin resistance measured by the homeostasis model assessment (HOMA-IR) and AAC assessed on lateral spine radiographs using the Framingham methodology. Results: Using a general linear model, statin use was associated with higher levels of HOMA-IR after stratified PS adjustment (beta = 1.52, [1.18 1.95], P < 0.01). Hydrophilic statin users (n = 9) and lipophilic statins users (n = 30) had higher HOMA-IR compared to nonstatin users (n = 125) ([beta= 2.29, (1.43-3.68), P < 0.001] and [beta = 1.36, (1.04-1.78), P < 0.05]), respectively, in general linear models after stratified PS adjustment. Statin use was associated with AAC without stratifying by PS in the Wilcoxon test, but was no longer significant when stratified by PS. Conclusions: Statins, widely prescribed drugs to lower cholesterol, may have unintended consequences related to glucose homeostasis that could be relevant in healthy aging. (C) Endocrine Society 2020.

The aim of this study was to test the effect of long-term dissolved CO2 exposure on white grouper (Epinephelus aeneus). 45 day post hatching (dph) groupers (0.4 +/- 0.05 g; 2.1 +/- 0.1 cm) were equally distributed to 15 aquaria (17 L) at a density of 40 larvae per aquarium. The fish were grown for 60 days at a salinity of 25 ppt (26.5 degrees C) while being exposed to three dissolved CO2 concentrations: Control (0.8 +/- 0.1 mg L-1; pH 7.9 +/- 0.1), Medium (5.5 +/- 0.2 mg L-1; pH 7.1 +/- 0.1) and High (28.5 +/- 1.5 mg L-1; pH 6.2 +/- 0.1). Analysis of bone mineral contents showed that at the end of the CO2 exposure period (105 dph), the Ca levels were significantly higher (P < .001) in the skeleton of fish from the high CO2 treatment as compared to the medium and control treatments. However, the P levels were not significantly different between the three treatments (P > .05). The gene expression of bone Gla protein (BGP, Osteocalcin), a marker for skeletal mineralization, was significantly higher in the vertebral column of the fish from the control treatment as compared to the medium (P < .05) and high (P < .01) treatments. The expression of BGP mRNA was positively correlated with the fish growth rate, as the fish from the control treatment presented the highest body weight at the end of the experiment.