Specificity
Detected in breast, colon, bone trabecular cells and fibroblasts.
Tag/Conjugate
Unconjugated
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Antigen Description
This gene encodes a member of the multicopper oxidase protein family. The encoded protein is involved in the transport of dietary iron from epithelial cells of the intestinal lumen into the circulatory system, and may be involved in copper transport and homeostasis. In mouse, defects in this gene can lead to severe microcytic anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Function
copper ion binding; ferrous iron binding; ferroxidase activity;
Synonyms
HEPH; hephaestin; CPL;
Citations
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Ranganathan, PN; Lu, Y; et al. Immunoreactive Hephaestin and ferroxidase activity are present in the cytosolic fraction of rat enterocytes. BIOMETALS 25:687-695(2012).
Hadziahmetovic, M; Dentchev, T; et al. Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 49:2728-2736(2008).